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Immunoregulatory effects of

Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, Cheng Xiao

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 556-563 doi: 10.1007/s11684-018-0649-5

Abstract: However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewedtheir effects for use in clinical practice.comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinicalstudies.

Keywords： Tripterygium wilfordii Hook F     immunoregulation     clinical studies    

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Progress of Brain Network Studies on Anesthesia and Consciousness: Framework and Clinical Applications Review

Jun Liu, Kangli Dong, Yi Sun, Ioannis Kakkos, Fan Huang, Guozheng Wang, Peng Qi, Xing Chen, Delin Zhang, Anastasios Bezerianos, Yu Sun

Engineering 2023, Volume 20, Issue 1,   Pages 77-95 doi: 10.1016/j.eng.2021.11.013

Abstract: This review summarizes recent research on brain network studies of anesthesia, and compares the underlyingWe demonstrate that whole-brain multimodal network data can provide important supplementary clinicalthat brain network methods, if simplified, will likely play an important role in improving the current clinical

Keywords： Anesthesia     Brain network     Connectivity     Graph theoretical analysis     Clinical monitoring system    

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Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 444-450 doi: 10.1007/s11684-012-0225-3

Abstract:

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variantsDeep sequencing followed by functional studies will be needed to elucidate the underpinning biological

Keywords： genome-wide association studies (GWAS)     genetic variant     cancer     limitation     challenge    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1694-0

Abstract:

● Data quality assessment criteria for MP/NPs in food products were developed.

Keywords： Microplastic     Nanoplastic     Food products     Data quality     Human health risk    

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Technical studies on high-speed turnouts for china railways

He Huawu

Strategic Study of CAE 2009, Volume 11, Issue 5,   Pages 23-30

Abstract:

High-speed turnout serves as a vital part of track structure for high-speed railway, and its structure and condition play an important role in train running safety and quality. In this paper, design parameters and linear plane of high-speed turnout, main structure characteristics of components (including fastening, turnout sleeper, switching system etc.), design theories of high-speed turnout, relevant technical requirements as well as innovative achievements are described, which will offer remarkable guiding significance for the further R&D, test, verification and wide-use of high-speed turnout in China railways.

Keywords： high-speed railway     high-speed turnout     technical studies    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies

Keywords： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization / toxicity tests    

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Experimental studies on extraction of cobalt ions from dilute aqueous solutions by using complexation-ultrafiltration

Jianxian ZENG, Junfeng LIU, Niandong HUANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 360-366 doi: 10.1007/s11705-009-0269-3

Abstract: The extraction of cobalt ions from dilute aqueous solutions was investigated by ultrafiltration with the help of poly(acrylic acid) sodium salt (PAASS). Polysulfone and polyethersulfone hollow fiber ultrafiltration membranes were employed in this process. The kinetics of complexation reaction was studied for PAASS with Co. Results showed that, under a large excess of PAASS, it takes 65, 55 and 40 min at pH 5, 6 and 7, respectively, to get the equilibrium of complexation. The reaction kinetics can be described by a pseudo-first-order equation. Then, the effects of various parameters on the extraction of Co were examined in detail. Results indicated that loading ratio, pH value and low-molecular competitive complexing agent affect significantly cobalt rejection coefficient . Furthermore, a concentration experiment was carried out at pH 7. With increasing volume concentration factor, membrane flux declines slowly, and value is always about 1. The concentrated retentate was used further for a decomplexation experiment. The decomplexation ratio of cobalt-PAASS complex reaches as high as 90.1%. After the decomplexation step, a diafiltration experiment was performed at pH 2.5. Cobalt ions can be extracted satisfactorily from the retentate, and a purified PAASS is obtained.
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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Parameter studies on impact in a lap joint

Amir M. RAHMANI,Elizabeth K. ERVIN

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 1,   Pages 64-77 doi: 10.1007/s11465-014-0322-x

Abstract:

To represent a loose lap joint, a beam impacting four springs with gaps is modeled. Modal analysis with base excitation is solved, and time histories of contact points are closely monitored. Using the impulse during steady state response, six influential parameters are studied: damping ratio, contact stiffness, intermediate contact position, gap, excitation amplitude and beam height. For all parameters, the system response is highly controlled by modes with two contacting springs. Each parameter’s effect on system response is presented including unstable regions, unique trend behaviours result. Recommendations for structural designers are also noted.

Keywords： impact mechanics     contact     joint behaviour     modal analysis     parameter study    

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Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl

Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 172-175 doi: 10.1007/s11705-009-0048-1

Abstract: The solubilities and densities of the aqueous metastable ternary systems (NaCl-MgCl -H O) and (KCl-MgCl -H O) at 308.15 K were determined by the isothermal evaporation method. On the basis of the experimental results, the phase diagrams for those systems were plotted. It was found that the former system belongs to the hydrate-I type with one invariant point of (NaCl+ MgCl ?6H O), two univariant curves, and two crystallization regions corresponding to halite (NaCl) and bischofite (MgCl ·6H O); and the latter system belongs to the type of incongruent-double salts with two invariant points of (KCl+ KCl·MgCl ·6H O) and (MgCl ·6H O+ KCl·MgCl ·6H O), three univariant curves, and three crystallization regions corresponding to potassium chloride (KCl), carnallite (KCl·MgCl ·6H O) and bischofite (MgCl ·6H O). No solid solutions were found in both systems.

Keywords： green chemistry     solar pond technique     simulation     metastable phase equilibrium     solubility    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Experimental studies on the influence of porosity on membrane absorption process

GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 385-389 doi: 10.1007/s11705-007-0070-0

Abstract: Eight kinds of flat membranes with different micro-structures were chosen to carry out the membrane absorption experiments with CO and de-ionized water or 0.1 mol · L NaOH solution as the experimental system. According to experimental results, the membrane pores shape (stretched pore and cylinder pore) and membrane thickness do not affect the membrane absorption process, and the membrane porosity has only little influence on membrane absorption process for slow mass transfer system. However, the influence of porosity on the membrane absorption process became visible for fast mass transfer system. Moreover, the mass transfer behavior near the membrane surface on liquid side was studied. The results show that the influence of membrane porosity on mass transfer relates to flow condition, absorption system and distance between micro-pores, etc.

Keywords： de-ionized     · L     different     membrane porosity     CO    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Title Author Date Type Operation

Immunoregulatory effects of

Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, Cheng Xiao

Journal Article

Progress of Brain Network Studies on Anesthesia and Consciousness: Framework and Clinical Applications

Jun Liu, Kangli Dong, Yi Sun, Ioannis Kakkos, Fan Huang, Guozheng Wang, Peng Qi, Xing Chen, Delin Zhang, Anastasios Bezerianos, Yu Sun

Journal Article

Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are

Journal Article

Technical studies on high-speed turnouts for china railways

He Huawu

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Journal Article

Experimental studies on extraction of cobalt ions from dilute aqueous solutions by using complexation-ultrafiltration

Jianxian ZENG, Junfeng LIU, Niandong HUANG,

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Parameter studies on impact in a lap joint

Amir M. RAHMANI,Elizabeth K. ERVIN

Journal Article

Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl

Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Experimental studies on the influence of porosity on membrane absorption process

GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article